Professor Phil Baker is an obstetrician scientist with a particular interest in the pregnancy complications preeclampsia and intrauterine growth restriction. These conditions are studied at a molecular, cellular, blood vessel and whole body level with each project interacting with and strengthening other projects.
Major ongoing efforts include the use of murine models to identify novel potential therapies for preeclampsia and intrauterine growth restriction, and the application of metabolomic technologies for patient benefits, particularly to develop screening tests for major pregnancy complications.
Other research interests have included: vascular adaptation to pregnancy, placental cell invasion, placental cell turnover, endothelial progenitor cells (EPCs), adverse pregnancy outcome in teenage pregnancies, fetal origins of adult disease (such as schizophrenia) and the effect of maternal stress on pregnancy outcome, and MRI imaging in pregnancy.
After training in Nottingham, Cambridge and Pittsburgh, Phil was appointed Professor of Obstetrics and Gynaecology at the University of Nottingham. There, he established a critical mass of researchers; the group was notable for having more abstracts accepted at the Society of Gynecologic Investigation than any other centre.
In addition to being the new Director of Gravida, Phil is also the Scientific Director of the International Pregnancy Research Alliance (IPRA). Previous posts include leadership of two medical schools and a successful Manchester (UK) application for a National Institute of Health Research Biomedical Research Centre (he was the inaugural director). He has been awarded grants totaling more than $40M for his own research portfolio; the majority of these grants relate to the study of the pathogenesis of pre-eclampsia and fetal growth restriction.
Phil is currently co-PI of an MRC (UK) programme grant and an EU FP7 programme grant. He has also led institutional research applications that have successfully accrued over $100M; several of these applications represent cross-institutional and cross-faculty interdisciplinary initiatives.
Phil’s ability to manage research is illustrated by over 300 scientific publications; more than 100 of these are with international co-authors. He holds visiting Professorships in Canada, China and the UK.